thermoregulatory dysfunction in covid 19

Front Immunol. Possible involvement of Syndecan-1 in the state of COVID-19 related to endothelial injury. Ni L, Wen Z, Hu X, Tang W, Wang H, Zhou L, et al. 2021;185:106469. CAS J Virol. It remains elusive whether COVID-19 patient should continue or initiate statin therapy. Poloni TE, Medici V, Moretti M, Vison SD, Cirrincione A, Carlos AF, et al. PEEP in COVID-19 Patients: A Retrospective Study on RV Dysfunction Maccio U, Zinkernagel AS, Shambat SM, Zeng X, Cathomas G, Ruschitzka F, et al. Cholinergic dysfunction in COVID-19: frantic search and hoping - PubMed 2021;24:152233. Circulatory exosomes from COVID-19 patients trigger NLRP3 inflammasome in endothelial cells. Clin (Sao Paulo, Braz). 2021;65:2226. Colchicine is an ancient and low-cost drug isolated from Chinese herbal medicine. Insights into endotheliopathy in COVID-19. The impact of heat waves on the mortality of Chinese population: A systematic review and meta-analysis. bioRxiv: the preprint server for biology 2021. https://doi.org/10.1101/2021.12.10.472112. 2020;56:2003167. Furthermore, it has been demonstrated that exosomes from severe COVID-19 patients trigger the activation of caspase-1 and NLRP3 inflammasome and release of IL-1 in ECs [64]. N Engl J Med. NO is one of the most important vasodilatory substances produced by the vascular endothelium with the action of the endothelial NO synthase (eNOS) and several cofactors. Moretta P, Maniscalco M, Papa A, Lanzillo A, Trojano L, Ambrosino P. Cognitive impairment and endothelial dysfunction in convalescent COVID-19 patients undergoing rehabilitation. 2021;7:9. Han T, Ma S, Sun C, Zhang H, Qu G, Chen Y, et al. J Mol Cell Cardiol. ACE2 is described as the first identified receptor responsible for the entry for SARS-CoV-2 into host cells including ECs [46]. Mechanistically, L-SIGN interacted with high-mannose-type N-glycans on the receptor-binding domain of SARS-CoV-2 spike protein in a Ca2+-dependent manner [33].

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